Chronic renal failure affects multiple systems in the body. Only some of these disorders can be improved by hemodialysis. Various disorders of thyroid functions are reported in patients with end-stage renal failure undergoing hemodialysis. Thyroid hormones are usually decreased in these patients, but there is controversy about the existence of true hypothyroidism. Hemodialysis also has an acute effect on thyroid hormones. Probable causes are encountered as improvement of hemodilution, loss of hormone by dialysate and effect of heparin used during hemodialysis. In these study we investigated thyroid hormone and TSH levels of patients undergoing regular hemodialysis (19 patients ,11 men, 8 women) before and after a single hemodialysis procedure, and compared the results with healthy controls {n:l3). In patient group, TT4 was significantly decreased, but there were no significant difference on TT4, fT3, fT4 and TSH between patients and controls. After hemodialysis, fT4,TT3 and TT4 increased significantly, but there were no significant difference on fT3 and TSH.
Keywords: Hemodialysis, Thyroid hormone.Kronik böbrek yetmezliği vücutta bütün sistemleri etkiler. Bozuk olan metabolik değişikliklerden ancak bir kısmı hemodiyaliz işlemi ile düzelmektedir. Hemodiyaliz tedavisi gören kronik böbrek yetmezlikli hastalarda tiroid fonksiyonlarında çeşitli bozukluklar bildirilmiştir. Tiroid hormonları bu hastalarda genellikle azalır. Bu çalışmada kronik böbrek yetersizliği i1e hemodiyaliz tedavisi gören hastalarda tek bir hemodiyaliz seansının tiroid fonksiyonlarına olan etkilerini araştırdık. Hemodiyaliz sonunda fT4, TT3 ve TT4 düzeyleri önemli ölçüde yükseldi, fT3 ve TSH düzeylerinde ise istatistiksel olarak anlamlı bir değişiklik gözlenmedi.
Anahtar Kelimeler: Hemodiyaliz. Tiroid hormonları.